Reactome | Chicken CD14 was reported to be involved in chicken TLR4 act...

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created	[InstanceEdit:975755] Shamovsky, V, 2010-10-04
dbId	975756
displayName	Chicken CD14 was reported to be involved in chicken TLR4 act...
literatureReference	[LiteratureReference:433898] Chicken CD14, unlike mammalian CD14, is trans-membrane rather than GPI-anchored [LiteratureReference:433799] Lipopolysaccharide binding protein/CD14/ TLR4-dependent recognition of salmonella LPS induces the functional activation of chicken heterophils and up-regulation of pro-inflammatory cytokine and chemokine gene expression in these cells
modified	[InstanceEdit:1112618] D'Eustachio, P, 2010-12-06
schemaClass	Summation
text	Chicken CD14 was reported to be involved in chicken TLR4 activation (Kogut et al 2005). It was cloned from chicken bone marrow cell RNA and is expressed in most lymphoid and non-lymphoid tissues (Wu Z et al 2009). Its cDNA encodes an open reading frame of 465 amino acids, which shares 31-34% identity to mouse, bovine and human CD14 amino acid sequences.

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