Reactome | SARS-CoV-2 encodes several proteins that have been implicate...

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created	[InstanceEdit:9754692] Shamovsky, Veronica, 2021-09-30
dbId	9754689
displayName	SARS-CoV-2 encodes several proteins that have been implicate...
literatureReference	[LiteratureReference:9754691] SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis [LiteratureReference:9729781] SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses
modified	[InstanceEdit:9765905] Shamovsky, Veronica, 2022-02-17
schemaClass	Summation
text	SARS-CoV-2 encodes several proteins that have been implicated in shutting off host expression (Banerjee AK et al. 2020; Finkel Y et al. 2021). This Reactome module describes SARS-CoV-2 nonstructural protein 1 (nsp1)-mediated shutdown of host protein translation by binding to the mRNA entrance channel on the 40S subunit (Banerjee AK et al. 2020), SARS-CoV-2 nsp16-mediated disruption of global mRNA splicing via binding to the 5? splice site recognition sequence of U1 snRNA and the branchpoint recognition site of U2 snRNA, both parts of the spliceosome (Banerjee et al, 2020), and SARS-CoV-2 nsp8, nsp9-mediated suppression of protein integration into the cell membrane (Banerjee et al, 2020).

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