After recruitment to activated FGFR mutants, FRS2 is believe...

created [InstanceEdit:9753849] Rothfels, Karen, 2021-09-15
dbId 9753850
displayName After recruitment to activated FGFR mutants, FRS2 is believe...
modified [InstanceEdit:9753867] Rothfels, Karen, 2021-09-15
schemaClass Summation
text After recruitment to activated FGFR mutants, FRS2 is believed to be phosphorylated, potentially on all 6 of the tyrosines phosphorylated by wild-type FGFRs. Phosphorylation of FRS2 by FGFR has been demonstrated in some cases (see for instance Qing, 2009; Bai, 2010; Ahmed, 2008; Raffioni, 1998) and is inferred to occur in others based on activation of downstream signaling modules (reviewed in Wesche, 2011; Turner and Grose, 2010; Parker et al, 2014; Carter et al, 2015).
Cite Us!