Reactome | Excretion of glucuronidated acetaminophen (APAP-GlcA) and su...

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created	[InstanceEdit:9753607] Jassal, Bijay, 2021-09-09
dbId	9753587
displayName	Excretion of glucuronidated acetaminophen (APAP-GlcA) and su...
literatureReference	[LiteratureReference:9753457] Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis
schemaClass	Summation
text	Excretion of glucuronidated acetaminophen (APAP-GlcA) and sulfated acetaminophen (APAP-SO3) into bile involves the ATP-binding cassette sub-family C member 2 transporter (ABCC2) and the broad substrate specificity ATP-binding cassette transporter (ABCG2), both found in the canalicular membrane of hepatocytes where they secrete drug conjugates into bile (Giacomini et al. 2010, Kidron et al. 2012, review McGill & Jaeschke 2013).

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