Interferon-gamma (IFNG) signaling was shown to induce nuclea...

created [InstanceEdit:9737555] Orlic-Milacic, Marija, 2021-07-20
dbId 9737554
displayName Interferon-gamma (IFNG) signaling was shown to induce nuclea...
schemaClass Summation
text Interferon-gamma (IFNG) signaling was shown to induce nuclear translocation of YBX1 and its binding to the promoter of the collagen I gene COL1A2 (Higashi et al. 2003). Based on studies in mice, phosphorylation of YBX1 on serine residues S32 and S36 (S30 and S34 in mouse Ybx1) by MAPK1 and/or MAPK3 (ERK2 and ERK1, respectively) is needed for the nuclear translocation of YBX1 and depends on JAK2, which may promote the interaction between YBX1 and ERKs (Jayavelu et al. 2020).
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