Bempedoic acid (ETC-1002) is first-in-class ATP-citrate lyas...

created [InstanceEdit:9735486] Jassal, Bijay, 2021-06-29
dbId 9735487
displayName Bempedoic acid (ETC-1002) is first-in-class ATP-citrate lyas...
schemaClass Summation
text Bempedoic acid (ETC-1002) is first-in-class ATP-citrate lyase (ACLY) inhibitor used once a day for reducing LDL cholesterol levels in statin-refractory patients. ETC-1002 itself is a prodrug, which is converted to the active metabolite ETC-1002?CoA by endogenous liver acyl-CoA synthetase (SLC27A2, ACSVL1) activity (Pinkosky et al. 2016).
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