Reactome | SARS-CoV-1 viroporin 3a is a membrane protein that transloca...

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created	[InstanceEdit:9731037] Stephan, Ralf, 2021-05-12
dbId	9731029
displayName	SARS-CoV-1 viroporin 3a is a membrane protein that transloca...
literatureReference	[LiteratureReference:9686326] SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death [LiteratureReference:9685946] The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function [LiteratureReference:9736324] The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death
modified	[InstanceEdit:9737723] Shamovsky, Veronica, 2021-07-21
schemaClass	Summation
text	SARS-CoV-1 viroporin 3a is a membrane protein that translocates to the plasma membrane and, via shedding, to other cells. It forms a homotetrameric inward-rectifying potassium ion channel by itself, causing cell death (Chan CM et al. 2009; Freundt EC et al. 2010; Yue Y et al. 2018). Additionally, monomeric 3a directly binds to and activates caspase-1 to cleave interleukin 1 beta thus contributing to the necrotic cell death (Yue Y et al, 2018).

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