Reactome | Alkylating chemotherapeutic drugs from the triazene group, d...

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created	[InstanceEdit:9730765] Orlic-Milacic, Marija, 2021-05-11
dbId	9730764
displayName	Alkylating chemotherapeutic drugs from the triazene group, d...
literatureReference	[LiteratureReference:9730876] DNA methylation in maternal, fetal and neonatal rat tissues following perinatal administration of procarbazine [LiteratureReference:9616000] Balancing repair and tolerance of DNA damage caused by alkylating agents [LiteratureReference:9730897] Alkylation of DNA in rat tissues following administration of streptozotocin
modified	[InstanceEdit:9750139] Orlic-Milacic, Marija, 2021-08-09
schemaClass	Summation
text	Alkylating chemotherapeutic drugs from the triazene group, dacarbazine (van Delft 1992), procarbazine (Wiestler et al. 1984 - study done in rats), temozolomide (Plummer et al. 2005), and streptozocin (streptozotocin) (Bennett and Pegg 1981 - study done in rats), produce N7-methylguanine adducts on double-stranded DNA (7meG-dsDNA). 7-methylguanine is the predominant methylation adduct produced by monofunctional alkylating chemotherapeutics, accounting for 60-80% of total alkylating lesions in DNA (reviewed by Fu et al. 2012).

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