SARS-CoV-2 nsp3 protease (PLpro) specifically cleaves IRF3 a...

created [InstanceEdit:9729750] Stephan, Ralf, 2021-05-03
dbId 9729722
displayName SARS-CoV-2 nsp3 protease (PLpro) specifically cleaves IRF3 a...
modified [InstanceEdit:9755977] Shamovsky, Veronica, 2021-10-12
schemaClass Summation
text SARS-CoV-2 nsp3 protease (PLpro) specifically cleaves IRF3 at the LGGG motif and decreases IRF3 levels in COVID-19. Infection with a mutant having inhibited protease activity did not decrease IRF3 levels, demonstrating that the decrease of IRF3 is linked to the protease activity of nsp3 (Moustaqil et al, 2021). The nsp3-mediated cleavage of IRF3 attenuates type I interferon responses.
Cite Us!