SARS-Cov-2 mRNA6 open reading frame has a length of 186 nt a...

created [InstanceEdit:9727294] Stephan, Ralf, 2021-04-15
dbId 9727282
displayName SARS-Cov-2 mRNA6 open reading frame has a length of 186 nt a...
literatureReference
modified [InstanceEdit:9734371] Stephan, Ralf, 2021-06-17
schemaClass Summation
text SARS-Cov-2 mRNA6 open reading frame has a length of 186 nt and encodes the 61 aa protein 6 (Wu et al, 2020). Protein 6 has a membrane-embedded alpha-helix on its N-terminus and initially localizes to the ER and the membranes of autophagosomes and lysosomes, as shown in HEK 293 T cells (Lee et al, 2021).

Protein 6 of SARS-Cov-2 has been shown in HEK 293 T cells to localize within 160 nm of nuclear pore complexes present at the nuclear envelope and at annulate lamellae in the cytoplasm, where it binds to the Nup98-Rae1 complex (Miorin et al, 2020).
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