SCN2A in combination with a regulatory beta subunit responds...

created [InstanceEdit:9725724] May, Bruce, 2021-03-31
dbId 9725726
displayName SCN2A in combination with a regulatory beta subunit responds...
literatureReference
schemaClass Summation
text SCN2A in combination with a regulatory beta subunit responds to depolarization by opening and passively transporting sodium ions according to the concentration gradient from the extracellular region to the cytosol (Ahmed et al. 1992, Ben-Shalom et al. 2017). In mouse type II taste cells, initial depolarization at the apex of the cell is believed to cause an activation potential via Scn2a, Scn3a, and Scn9a located at the basolateral membrane (Gao et al. 2009). Differences in SCN2A alleles appear to be related to autism spectrum disorder (Ben-Shalom et al. 2017).
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