SH2B3 (also called LNK) is an adaptor protein that binds to ...

created [InstanceEdit:9706314] Rothfels, Karen, 2020-11-04
dbId 9706316
displayName SH2B3 (also called LNK) is an adaptor protein that binds to ...
schemaClass Summation
text SH2B3 (also called LNK) is an adaptor protein that binds to tyrosine phosphorylated FLT3 through at least 3 tyrosine residues, Y572, Y591 and Y919 (Lin et al, 2012). SH3B2 is a known CBL interactor, so may contribute to FLT3 downregulation by promoting the CBL-dependent ubiquitination and internalization of the receptor, although this hasn't been formally demonstrated (Lv et al, 2017; Lin et al, 2012; reviewed in Kazi and Ronnstrand, 2019).
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