KW-2449 is a second generation, type I aurora kinase and FLT...

created [InstanceEdit:9703054] Rothfels, Karen, 2020-10-05
dbId 9703055
displayName KW-2449 is a second generation, type I aurora kinase and FLT...
schemaClass Summation
text KW-2449 is a second generation, type I aurora kinase and FLT3 tyrosine kinase inhibitor, Despite effectiveness against a number of FLT3 mutant alleles, it has been withdrawn from development due to poor pharmacodynamics (reviewed in Larrosa-Garcia and Baer, 2017; Kazi and Roonstrand, 2019). This pathway describes FLT3 mutants that are resistant to inhibition by KW-2449.
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