Reactome | Amin, HM

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created	[InstanceEdit:9699723] Rothfels, Karen, 2020-09-14
dbId	9699720
displayName	Amin, HM
firstname	Hesham M
initial	HM
publications	[LiteratureReference:9701338] Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma [LiteratureReference:9701413] Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma [LiteratureReference:9701407] Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma [LiteratureReference:9701315] JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells [LiteratureReference:9702302] The ALK inhibitor ASP3026 eradicates NPM-ALK? T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model [LiteratureReference:9701408] Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma [LiteratureReference:9699725] Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma [LiteratureReference:9931284] IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion
schemaClass	Person
surname	Amin

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