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The pseudokinase mixed lineage kinase domain-like (MLKL), is... Show undefined attributes

created	[InstanceEdit:9698845] Shamovsky, Veronica, 2020-08-30
dbId	9698848
displayName	The pseudokinase mixed lineage kinase domain-like (MLKL), is...
literatureReference	[LiteratureReference:9698850] An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client [LiteratureReference:9688457] HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death [LiteratureReference:9688477] Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis [LiteratureReference:9698655] The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL)
modified	[InstanceEdit:9948067] Shamovsky, Veronica, 2025-05-15
schemaClass	Summation
text	The pseudokinase mixed lineage kinase domain-like (MLKL), is the terminal known obligatory effector in the necroptosis pathway, and is activated following phosphorylation by receptor interacting protein kinase-3 (RIPK3). Activated MLKL translocates to membranes, leading to membrane destabilisation and subsequent cell death. Heat?shock protein 90 (HSP90) and cell division cycle 37 (CDC37) cochaperone complex contributes to activation of MLKL (Jacobsen AV et al. 2016; Zhao XM et al. 2016; Bigenzahn JW et al. 2016). It remains unclear whether HSP90 influences MLKL folding, oligomerization, or membrane translocation, though it is plausible that HSP90 affects all of these activation steps (Murphy JM 2020).

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[Reaction:R-HSA-9698844] MLKL binds HSP90:CDC37

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