Reactome | This COVID-19 pathway has been created by a combination of c...

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created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
dbId	9694747
displayName	This COVID-19 pathway has been created by a combination of c...
literatureReference	[LiteratureReference:9682922] Expression of SARS-coronavirus envelope protein in Escherichia coli cells alters membrane permeability [LiteratureReference:9682946] Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein [LiteratureReference:9683075] The envelope protein of severe acute respiratory syndrome coronavirus interacts with the non-structural protein 3 and is ubiquitinated
modified	[InstanceEdit:9698837] Stephan, Ralf, 2020-08-30
schemaClass	Summation
text	This COVID-19 pathway has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. The envelope protein (E) gets palmitoylated and ubiquitinated after translation. It forms trimers that show porin activity but does not localize to the cell membrane (Tan et al, 2004; Liao et al, 2006; Alvarez et al, 2011)

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