Reactome | SARS-CoV-2 plus strand genomic RNA (gRNA), like genomic RNAs...

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created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
dbId	9694654
displayName	SARS-CoV-2 plus strand genomic RNA (gRNA), like genomic RNAs...
literatureReference	[LiteratureReference:9680317] Host protein interactions with the 3' end of bovine coronavirus RNA and the requirement of the poly(A) tail for coronavirus defective genome replication [LiteratureReference:9685588] Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus Polyadenylation [LiteratureReference:9685589] Identification and Characterization of a Human Coronavirus 229E Nonstructural Protein 8-Associated RNA 3'-Terminal Adenylyltransferase Activity [LiteratureReference:9697214] The Architecture of SARS-CoV-2 Transcriptome
modified	[InstanceEdit:9697273] Orlic-Milacic, Marija, 2020-08-12
schemaClass	Summation
text	SARS-CoV-2 plus strand genomic RNA (gRNA), like genomic RNAs of SARS-CoV-1 and other coronaviruses, is polyadenylated. The poly(A) tail of gRNA is longer than the poly(A) tail of subgenomic SARS-CoV-2 RNAs (Kim et al. 2020). Coronavirus plus strand gRNAs possess a polyadenylation signal in their 3'UTR and are polyadenylated by an undetermined viral RNA polymerase, possibly nsp8 or nsp12 (Spagnolo and Hogue 2000, Peng et al. 2016, Tvarogova et al. 2019).

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