Reactome | nsp13, which functions as the viral helicase, is as a part o...

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created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
dbId	9694391
displayName	nsp13, which functions as the viral helicase, is as a part o...
literatureReference	[LiteratureReference:9682622] Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis [LiteratureReference:9682644] Mechanism of nucleic acid unwinding by SARS-CoV helicase [LiteratureReference:9682655] Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome [LiteratureReference:9697033] Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex
modified	[InstanceEdit:9697100] Orlic-Milacic, Marija, 2020-08-05
schemaClass	Summation
text	nsp13, which functions as the viral helicase, is as a part of the SARS coronavirus 2 (SARS-CoV-2) replication-transcription complex (RTC). Two molecules of SARS-CoV-2 nsp13 are found in the RTC complex. N-terminal domains of each nsp13 interact with N-terminal extensions of each copy of nsp8, while nsp13 molecule interacts with the thumb region of nsp12, the viral RNA-dependent RNA polymerase. One nsp13 molecule of SARS-CoV-2 is tightly bound to the RTC, while the other nsp13 molecule is dissociable (Chen et al. 2020). In SARS-CoV-1, nsp13 has been reported to directly interact with nsp12, and nsp12 was shown to increase the helicase activity of nsp13 (von Brunn et al. 2007, Adedeji et al. 2012, Jia et al. 2019).

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