Upon secretion from the cell, FVIII circulates in a tight co...
| created | [InstanceEdit:9672398] Shamovsky, Veronica, 2019-12-25 |
| dbId | 9672392 |
| displayName | Upon secretion from the cell, FVIII circulates in a tight co... |
| literatureReference | |
| modified | [InstanceEdit:9674513] Shamovsky, Veronica, 2020-01-13 |
| schemaClass | Summation |
| text | Upon secretion from the cell, FVIII circulates in a tight complex with the multimeric glycoprotein von Willebrand Factor (vWF), which is essential for maintaining stable levels of FVIII in the circulation (reviewed by Pipe SW et al. 2016). Genetic mutations in the F8 gene can compromise FVIII binding to vWF thus decreasing FVIII values in the plasma causing hemophilia A (HA), an X-linked recessive bleeding disorder. |
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