Reactome | Transcription of the telomeric noncoding RNA TERRA (the telo...

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created	[InstanceEdit:9670564] Orlic-Milacic, Marija, 2019-12-10
dbId	9670559
displayName	Transcription of the telomeric noncoding RNA TERRA (the telo...
literatureReference	[LiteratureReference:9670568] Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors [LiteratureReference:9670557] Systematic analysis of telomere length and somatic alterations in 31 cancer types
modified	[InstanceEdit:9672909] Orlic-Milacic, Marija, 2020-01-03
schemaClass	Summation
text	Transcription of the telomeric noncoding RNA TERRA (the telomere repeat-containing RNA) is inhibited by ATRX (Flynn et al. 2015). Tumors with ATRX and DAXX mutations associated with the alternative lengthening of telomeres (ALT) show increased TERRA levels (Barthel et al. 2017).

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