Reactome | Chiarle, R

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created	[InstanceEdit:9667875] Orlic-Milacic, Marija, 2019-11-18
dbId	9667884
displayName	Chiarle, R
firstname	Roberto
initial	R
publications	[LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer [LiteratureReference:9701357] Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target [LiteratureReference:9701343] NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors [LiteratureReference:9701321] Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death [LiteratureReference:9850777] NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells [LiteratureReference:9850784] The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway [LiteratureReference:9725240] Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes [LiteratureReference:9710822] The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration [LiteratureReference:9701354] ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis [LiteratureReference:9843025] IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma
schemaClass	Person
surname	Chiarle

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