Gasdermin D (GSDMD) is a member of the gasdermin (GSDM) prot...
| created | [InstanceEdit:9647682] Shamovsky, Veronica, 2019-06-03 |
| dbId | 9647691 |
| displayName | Gasdermin D (GSDMD) is a member of the gasdermin (GSDM) prot... |
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| modified | [InstanceEdit:9710222] Shamovsky, Veronica, 2020-12-25 |
| schemaClass | Summation |
| text | Gasdermin D (GSDMD) is a member of the gasdermin (GSDM) protein family, which is processed by inflammatory caspases and cleaved into an N?terminal (GSDMD(1-275)) and a C?terminal (GSDMD (276-484)) fragments (Shi J et al, 2015). Once GSDMD is cleaved, the N-terminal fragment of GSDMD (1-275) targets and permeabilizes cellular membranes by assembling transmembrane pores (Ding J et al, 2016; Liu X et al, 2016; Sborgi L et al, 2016). High?resolution (? 2 nm) atomic force microscopy (AFM) showed that GSDMD N-terminus inserts into various lipid membranes (Mulvihill E et al. 2018). Once inserted, the N-terminal fragment of GSDMD assembles arc?, slit?, and ring?shaped oligomers, which eventually incorporate additional oligomers and transform into larger thermodynamically stable ring?shaped oligomers (Mulvihill E et al. 2018). |
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