Reactome | Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity

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Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity Show undefined attributes

author	[Person:9647019] Hu, Z [Person:9646936] Wan, X [Person:9646956] Hao, R [Person:2028659] Zhang, H [Person:5321651] Li, L [Person:5321510] Li, L [Person:9646966] Xie, Q [Person:5251212] Wang, P [Person:9647010] Gao, Y [Person:5218910] Chen, S [Person:5251129] Wei, M [Person:9646979] Luan, Z [Person:9646976] Zhang, A [Person:9646943] Huang, N [Person:5660149] Chen, L
created	[InstanceEdit:9647017] Orlic-Milacic, Marija, 2019-05-29
dbId	9646962
displayName	Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity
journal	PLoS ONE
pages	e0123623
pubMedIdentifier	25853726
schemaClass	LiteratureReference
title	Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity
url	http://www.ncbi.nlm.nih.gov/pubmed/25853726
volume	10
year	2015

Referrals

(literatureReference)

[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants
[Summation:9664945] For the following EGFR-binding ERBB2 KD mutants that were sh...
[Reaction:R-HSA-9664940] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3
[Reaction:R-HSA-9665032] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1
[Reaction:R-HSA-9665034] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1
[Summation:9664930] For the following EGFR-binding ERBB2 KD mutants that activat...
[Reaction:R-HSA-9664933] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
[Reaction:R-HSA-9665121] ERBB2 KD mutants bind TKIs
[Reaction:R-HSA-9664991] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants
[Summation:9664919] Many EGFR-binding ERBB2 KD mutants were shown to activate PI...
[Reaction:R-HSA-9664918] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1
[Reaction:R-HSA-9664664] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3
[Reaction:R-HSA-9664646] Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K
[EntityWithAccessionedSequence:R-HSA-9654833] p-Y-ERBB2 H878Y [plasma membrane]
[Reaction:R-HSA-9664983] Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1
[Reaction:R-HSA-9664976] Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1
[Reaction:R-HSA-9664950] Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1
[Reaction:R-HSA-9665009] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR
[Reaction:R-HSA-9665000] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1
[Reaction:R-HSA-9664588] ERBB2 KD mutants trans-autophosphorylate
[EntityWithAccessionedSequence:R-HSA-9646824] ERBB2 H878Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647215] p-6Y-ERBB2 H878Y [plasma membrane]

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