The roughly constant numbers of Mycobacterium tuberculosis (...

created [InstanceEdit:9637696] Jassal, Bijay, 2019-02-19
dbId 9637691
displayName The roughly constant numbers of Mycobacterium tuberculosis (...
modified [InstanceEdit:9915435] Stephan, Ralf, 2024-07-06
schemaClass Summation
text The roughly constant numbers of Mycobacterium tuberculosis (Mtb) during the chronic phase of infection are due to a balance between rapid replication and death (McDaniel et al. 2016). The relatively safe environment for Mtb in the phagocyte's phagosome is overcome when about 20-25 bacterial cells accumulate (Repasy et al. 2013). First, the phagosomal membrane is destroyed. Then, by injuring mitochondria and depleting NAD+, cell necrosis is started, resulting in Mtb escape (Lee et al. 2011).
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