Reactome | Missense mutations and small indels in the CDKN2A gene, whic...

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created	[InstanceEdit:9633891] Orlic-Milacic, Marija, 2019-01-02
dbId	9633892
displayName	Missense mutations and small indels in the CDKN2A gene, whic...
literatureReference	[LiteratureReference:9633925] Tumor suppressor genes and ROS: complex networks of interactions [LiteratureReference:9633908] Replicative senescence and oxidant-induced premature senescence. Beyond the control of cell cycle checkpoints [LiteratureReference:9645259] Impaired inhibition of NF-kappaB activity by melanoma-associated p16INK4a mutations
modified	[InstanceEdit:9645275] Orlic-Milacic, Marija, 2019-05-07
schemaClass	Summation
text	Missense mutations and small indels in the CDKN2A gene, which result in amino acid changes in p16INK4A that impair its ability to bind to CDK4, interfere with p16INK4A-mediated, oxidative stress-induced, cellular senescence (Chen 2000, Vurusaner et al. 2012). Loss-of-function mutations in p16INK4A can also contribute to cancer by interfering with p16INK4A-mediated inhibition of NFKB signaling (Becker et al. 2005).

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