Reactome | A histone deacetylase SIRT1 deacetylates FOXO1. Deacetylatio...

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created	[InstanceEdit:9626961] Orlic-Milacic, Marija, 2018-10-30
dbId	9626960
displayName	A histone deacetylase SIRT1 deacetylates FOXO1. Deacetylatio...
literatureReference	[LiteratureReference:9626714] Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity [LiteratureReference:9626711] Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
modified	[InstanceEdit:9626971] Orlic-Milacic, Marija, 2018-10-30
schemaClass	Summation
text	A histone deacetylase SIRT1 deacetylates FOXO1. Deacetylation increases FOXO1-mediated upregulation of SOD2 and CDKN1B (Diatoku et al. 2004). SIRT-dependent deacetylation leads to retention of FOXO1 in the nucleus (Frescas et al. 2005).

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