A cell containing a repressed or latent Human Cytomegaloviru...

created [InstanceEdit:9614825] Gillespie, Marc E, 2018-07-27
dbId 9614827
displayName A cell containing a repressed or latent Human Cytomegaloviru...
literatureReference
modified [InstanceEdit:9663588] Gillespie, Marc E, 2019-10-04
schemaClass Summation
text A cell containing a repressed or latent Human Cytomegalovirus (HCMV) genome sits quietly carrying on its normal cellular functions. The HCMV silenced HCMV geneome can be activated by a number of celluar events or state changes. Reactivation of HCMV lytic infection is correlated to changes in histone modifications around the MIEP promoter resulting in a new chromatin structure conducive to transcriptional activity. These changes are intimately linked with cell differentiation, a phenomenon known to reactivate latent virus in vivo.
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