As part of the HCMV Vesicle Formation Complex, Vps4 controls...

created [InstanceEdit:9610943] Guerreiro, Carolina, 2018-06-13
dbId 9610953
displayName As part of the HCMV Vesicle Formation Complex, Vps4 controls...
literatureReference
modified [InstanceEdit:9663712] Gillespie, Marc E, 2019-10-10
schemaClass Summation
text As part of the HCMV Vesicle Formation Complex, Vps4 controls the release of ESCRT complexes from membranes. Upstream ESCRT complexes ESCRT-I and ESCRT-II are believed to work in parallel to recruit the cargo, whereas Vps4 and ESCRT-III work in series. Virus envelopment occurs by budding into endosomal vesicles, which fuse with the plasma membrane to release virions to the extracellular space. Accumulation of viral glycoproteins gM-gN and ESCRT proteins at the periphery of AC support this model of viral egress, where these proteins provide essential functions such as envelopment and endosomal budding before viral exit.
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