Reactome | GluN1 (GRIN1) forms a di-heterotetrameric complex with GluN2...

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created	[InstanceEdit:9609971] Orlic-Milacic, Marija, 2018-06-04
dbId	9609972
displayName	GluN1 (GRIN1) forms a di-heterotetrameric complex with GluN2...
literatureReference	[LiteratureReference:9609978] Heteromeric NMDA receptors: molecular and functional distinction of subtypes [LiteratureReference:9609810] NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease [LiteratureReference:9637113] Region-specific Expression of NMDA Receptor GluN2C Subunit in Parvalbumin-Positive Neurons and Astrocytes: Analysis of GluN2C Expression using a Novel Reporter Model [LiteratureReference:9637116] Novel regional and developmental NMDA receptor expression patterns uncovered in NR2C subunit-beta-galactosidase knock-in mice [LiteratureReference:9627458] Glutamate receptor ion channels: structure, regulation, and function
modified	[InstanceEdit:9637122] Orlic-Milacic, Marija, 2019-02-14
schemaClass	Summation
text	GluN1 (GRIN1) forms a di-heterotetrameric complex with GluN2C (GRIN2C) in heterologous expression systems. The tetramer includes two molecules of GluN1 and two molecules of GluN2C (Monyer et al. 1994). The stoichiometry in neurons remains to be determined. GluN2C expression starts late during embryonic development and is most prominent in cerebellum, olfactory bulb, and glial cells (Karavanova et al. 2007, Ravikrishnan et al. 2018, reviewed by Traynelis et al. 2010, Paoletti et al. 2013).

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