Reactome | R�nnstrand, L

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R�nnstrand, L Show undefined attributes

created	[InstanceEdit:9606953] May, Bruce, 2018-04-30
dbId	9606963
displayName	R�nnstrand, L
firstname	Lars
initial	L
publications	[LiteratureReference:381858] Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma [LiteratureReference:1433283] Signal transduction via the stem cell factor receptor/c-Kit [LiteratureReference:163546] Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro [LiteratureReference:175971] Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases [LiteratureReference:382036] Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases [LiteratureReference:205330] Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C [LiteratureReference:1433556] The stem cell factor receptor/c-Kit as a drug target in cancer [LiteratureReference:1472107] Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3 [LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications [LiteratureReference:9697902] The role of SRC family kinases in FLT3 signaling [LiteratureReference:9706098] FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia [LiteratureReference:9706144] Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling [LiteratureReference:9706132] Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling [LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors [LiteratureReference:1562567] Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit [LiteratureReference:9672939] The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction [LiteratureReference:9605263] FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia [LiteratureReference:9706150] The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation [LiteratureReference:1433489] Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells [LiteratureReference:205327] Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor [LiteratureReference:1433318] Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant [LiteratureReference:1433370] Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl [LiteratureReference:1562587] Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation [LiteratureReference:9703529] Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation [LiteratureReference:9706120] SOCS proteins in regulation of receptor tyrosine kinase signaling [LiteratureReference:382023] Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation [LiteratureReference:9604740] Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation [LiteratureReference:9604764] A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival [LiteratureReference:1362219] Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block [LiteratureReference:9941805] Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A [LiteratureReference:381883] Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins [LiteratureReference:205273] The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit [LiteratureReference:1472104] Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk [LiteratureReference:9706095] Expression of GADS enhances FLT3-induced mitogenic signaling [LiteratureReference:1433319] Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction [LiteratureReference:9706148] Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3 [LiteratureReference:9706157] The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling [LiteratureReference:9604777] Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2 [LiteratureReference:1562593] Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase [LiteratureReference:9680538] Src family kinases are involved in the differential signaling from two splice forms of c-Kit [LiteratureReference:9697873] SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML [LiteratureReference:9706142] Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling [LiteratureReference:9697866] Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling [LiteratureReference:2685412] Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases [LiteratureReference:9706128] SYK is a critical regulator of FLT3 in acute myeloid leukemia [LiteratureReference:9706062] Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3 [LiteratureReference:9697909] Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD [LiteratureReference:9706052] ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling
schemaClass	Person
surname	R�nnstrand

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