Reactome | The liver X receptor alpha (LXR? or NR1H3) mRNA is translate...

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created	[InstanceEdit:9605053] Shamovsky, Veronica, 2018-04-06
dbId	9605059
displayName	The liver X receptor alpha (LXR? or NR1H3) mRNA is translate...
literatureReference	[LiteratureReference:9038557] MicroRNA hsa-miR-613 targets the human LXR? gene and mediates a feedback loop of LXR? autoregulation [LiteratureReference:9631344] MicroRNA-1 and microRNA-206 suppress LXR?-induced lipogenesis in hepatocytes [LiteratureReference:9631347] miR-206 controls LXR? expression and promotes LXR-mediated cholesterol efflux in macrophages
modified	[InstanceEdit:9658380] Shamovsky, Veronica, 2019-08-13
schemaClass	Summation
text	The liver X receptor alpha (LXR? or NR1H3) mRNA is translated to yield NR1H3 protein. MicroRNAs miR-1, miR-206 and miR-613 have been identified as negative regulators of NR1H3 expression and lipogenesis in the liver (Zhong D et al. 2013; Ou Z et al. 2011). Interestingly, miR-206 also regulates NR1H3 in macrophages but in an opposing manner relative to liver (Vinod M et al. 2014). Stably overexpressing miR-206 in THP-1 human macrophages revealed an up-regulation of NR1H3 and miR-206 knockdown led to a down-regulation of NR1H3 and its target genes (Vinod M et al. 2014).

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