8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

accession 0035539
created [InstanceEdit:937668] Yung, CK
databaseName GO
dbId 937889
definition Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
displayName 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
ecNumber 3.6.1.55
modified [InstanceEdit:9676538] Cook, Justin, 2020-02-17
name 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
referenceDatabase [ReferenceDatabase:1] GO
schemaClass GO_MolecularFunction
url https://www.ebi.ac.uk/QuickGO/term/GO:0035539

Referrals

(activity)
Cite Us!