ISG15 is an ubiquitin (Ub)-like protein which is conjugated ...

created [InstanceEdit:936537] Garapati, P V, 2010-08-23
dbId 936538
displayName ISG15 is an ubiquitin (Ub)-like protein which is conjugated ...
literatureReference
modified [InstanceEdit:9927236] Shamovsky, Veronica, 2024-11-05
schemaClass Summation
text ISG15 is an ubiquitin (Ub)-like protein which is conjugated to intracellular proteins via an isopeptide bond. Similar to ubiquitination, the conjugation of ISG15 (ISGylation) requires a three-step process, involving an E1 activating enzyme (UBE1L), an E2 conjugating enzyme (UbcM8/H8), and HERC5/Ceb1 an IFN-inducible ISG15-specific E3 ligase. ISG15 conjugation may play an important regulatory role in IFN-mediated antiviral responses. IFN induces ISG15 conjugation to DDX58 (RIG-I) negatively regulating DDX58-mediated antiviral signaling. ISGylated DDX58 (RIG-I) becomes subject to an irreversible biochemical process, such as proteolysis or proteasomeal degradation.
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