As with other cytokine systems, production of type I IFN is ...

created [InstanceEdit:936486] Garapati, P V, 2010-08-23
dbId 936487
displayName As with other cytokine systems, production of type I IFN is ...
literatureReference
modified [InstanceEdit:9927234] Shamovsky, Veronica, 2024-11-05
schemaClass Summation
text As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I (DDX58) and MDA5 (IFIH1).
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