Autophagy protein 5 (ATG5) and autophagy-related protein 12 ...

created [InstanceEdit:936409] Garapati, P V, 2010-08-22
dbId 936432
displayName Autophagy protein 5 (ATG5) and autophagy-related protein 12 ...
literatureReference
modified [InstanceEdit:8983918] Jupe, Steve, 2017-03-31
schemaClass Summation
text Autophagy protein 5 (ATG5) and autophagy-related protein 12 (ATG12) conjugate negatively regulates the type I IFN production pathway by directly associating with DDX58/IFIH1 and MAVS through the caspase recruitment domains (CARDs). The ATG5-ATG12 conjugate intercalates between the CARDs of DDX58/IFIH1 and MAVS and inhibits signal transmission, resulting in suppression of type I IFN production and innate antiviral immune responses.
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