Reactome | RAP1GAP2 binds 14-3-3 proteins beta and zeta, inhibiting its...

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created	[InstanceEdit:913995] Jupe, S, 2010-07-20
dbId	913990
displayName	RAP1GAP2 binds 14-3-3 proteins beta and zeta, inhibiting its...
literatureReference	[LiteratureReference:913997] Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets [LiteratureReference:430240] Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets
modified	[InstanceEdit:939804] Jupe, S, 2010-09-01
schemaClass	Summation
text	RAP1GAP2 binds 14-3-3 proteins beta and zeta, inhibiting its GAP activity for Rap1. This effect is diminished by Ser-7 phosphorylation of RAP1GAP2 by cGMP- and cAMP-dependent protein kinases (PKG and PKA respectively), which inhibits the binding of 14-3-3 proteins beta and zeta to Rap1GAP2. 14-3-3 binding does not appear to alter the GTPase-activating function of Rap1GAP2 in vitro, but attenuates Rap1GAP2 mediated inhibition of cell adhesion (Hoffmeister et al. 2008).

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