Reactome | Endonuclease-exonuclease-phosphatase family domain containin...

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created	[InstanceEdit:9035177] Shamovsky, Veronica, 2018-01-18
dbId	9035195
displayName	Endonuclease-exonuclease-phosphatase family domain containin...
literatureReference	[LiteratureReference:9035144] EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux [LiteratureReference:9035131] Genome-wide analysis of LXR? activation reveals new transcriptional networks in human atherosclerotic foam cells
modified	[InstanceEdit:9658427] Shamovsky, Veronica, 2019-08-14
schemaClass	Summation
text	Endonuclease-exonuclease-phosphatase family domain containing 1 (EEPD1/KIAA1706) was identiified as a direct transcriptional target of liver X receptors (LXR alpha (NR1H3) and LXR beta (NR1H2)) in murine bone marrow-derived macrophages (BMDM), J774 macrophages and in human monocyte-like THP-1 cells (Nelson JK et al. 2017). An LXR alpha (NR1H3) ChIP-seq study identified a LXR-response element (LXRE) in intron 2 of EEPD1 gene (Nelson JK et al. 2017; Feldmann R et al. 2013).

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