Reactome | In transient transfection assays performed in human hepatoma...

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created	[InstanceEdit:9029533] Shamovsky, Veronica, 2017-11-20
dbId	9029523
displayName	In transient transfection assays performed in human hepatoma...
literatureReference	[LiteratureReference:9609427] Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression [LiteratureReference:9024438] The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice
modified	[InstanceEdit:9658477] Shamovsky, Veronica, 2019-08-14
schemaClass	Summation
text	In transient transfection assays performed in human hepatoma HepG2 cells, NR1H3 (LXR alpha) was found to interact with the nuclear receptor corepressor (NCOR) and nuclear receptor coactivator 1 (NCOA1 or SRC1) to regulate the UGT1A3 gene promoter (Verreault M et al. 2006). In the unliganded state, LXR:RXR heterodimers are bound to DNA response elements in association with co-repressor complexes resulting in repression of target genes (Wagner BL et al. 2003). Ligand binding to LXR induces conformational changes leading to release of co-repressor complexes and recruitment of co-activator complexes and transcription of target genes.

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