Reactome | It is proposed that prostaglandin J3 (PGJ3) isomerises to pr...

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created	[InstanceEdit:9028211] Jassal, Bijay, 2017-11-07
dbId	9028224
displayName	It is proposed that prostaglandin J3 (PGJ3) isomerises to pr...
literatureReference	[LiteratureReference:9028203] 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes [LiteratureReference:9028229] Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia [LiteratureReference:9028296] ?12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
modified	[InstanceEdit:9955867] D'Eustachio, Peter, 2025-06-11
schemaClass	Summation
text	It is proposed that prostaglandin J3 (PGJ3) isomerises to prostaglandin ?12-PGJ3 (?12-PGJ3) (Fitzpatrick et al. 1983, Shibata et al. 2002). EPA supplementation to mice resulted in enhanced endogenous production of ?12-PGJ3, which was found to possess chemoprotective activity against myleoid leukemia, ablating leukemia stem cells in mice (Hegde et al. 2011, Finch et al. 2015).

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