In neutrophils, an epoxide hydrolase can hydrolyse 16(S),17(...
| created | [InstanceEdit:9026043] Jassal, Bijay, 2017-10-17 |
| dbId | 9026049 |
| displayName | In neutrophils, an epoxide hydrolase can hydrolyse 16(S),17(... |
| literatureReference | |
| modified | [InstanceEdit:9028878] Jassal, Bijay, 2017-11-13 |
| schemaClass | Summation |
| text | In neutrophils, an epoxide hydrolase can hydrolyse 16(S),17(S)-epoxy-docosapentaenoic acid (16(S),17(S)-epoxy-DPAn-3) to either 10(R),17(S)-dihydroxy-docosapentaenoic acid (PD1n-3DPA) or 16,17(S)-dihydroxy-docosapentaenoic acid (PD2n-3DPA) (Dalli et al. 2013). The formation of these protectins is supported by chemical synthesis experiments (Aursnes et al. 2014, Primdahl et al. 2017). These DPAn-3-derived protectins demonstrate potent anti-inflammatory activities together with pro-resolving actions, stimulating human macrophage phagocytosis and efferocytosis (Dalli et al. 2013, Aursnes et al. 2014, Primdahl et al. 2017, Gobbetti et al. 2017). |
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