Reactome | MicroRNA miR-132 is complementary to the 3'UTR of long MECP2...

Schema > Summation > Entries

created	[InstanceEdit:9021223] Orlic-Milacic, Marija, 2017-09-15
dbId	9021222
displayName	MicroRNA miR-132 is complementary to the 3'UTR of long MECP2...
literatureReference	[LiteratureReference:9021209] MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA?132 in rats with depression [LiteratureReference:9021085] Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA [LiteratureReference:9615505] Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs [LiteratureReference:9615491] A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
modified	[InstanceEdit:9615855] Orlic-Milacic, Marija, 2018-08-08
schemaClass	Summation
text	MicroRNA miR-132 is complementary to the 3'UTR of long MECP2 transcripts (>10 kb), which are predominantly expressed in the brain. Based on studies in mice and rats, miR-132 reduces both mRNA and protein levels of MECP2 and was confirmed to be specific for MECP2 mRNA by the 3'UTR-luciferase reporter gene assay (Klein et al. 2007, Su et al. 2015). miR-132 levels increase in response to BDNF signaling in a CREB-dependent way (Vo et al. 2005, Klein et al. 2007, Lyu et al. 2016). In patients with major depressive disorder, miR-132 levels are increased while MECP2 and BDNF levels are decreased (Su et al. 2015).

(summation)

Cite Us!