Reactome | NOTCH4 expression correlates with increased HES1 gene transc...

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created	[InstanceEdit:9013722] Orlic-Milacic, Marija, 2017-07-25
dbId	9013725
displayName	NOTCH4 expression correlates with increased HES1 gene transc...
literatureReference	[LiteratureReference:9604432] Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh) [LiteratureReference:9604426] Active form Notch4 promotes the proliferation and differentiation of 3T3-L1 preadipocytes [LiteratureReference:9604524] Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity
modified	[InstanceEdit:9604549] Orlic-Milacic, Marija, 2018-04-04
schemaClass	Summation
text	NOTCH4 expression correlates with increased HES1 gene transcription in different cell types (Raafat et al. 2004, Lai et al. 2013, Simoes et al. 2015). A recombinant human NICD4 stimulates transcription from the recombinant human HES1-luciferase reporter construct (Raafat et al. 2004).

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