Interleukins (IL) are immunomodulatory proteins that elicit ...
| created | [InstanceEdit:9008601] Varusai, Thawfeek, 2017-06-12 |
| dbId | 9008609 |
| displayName | Interleukins (IL) are immunomodulatory proteins that elicit ... |
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| modified | [InstanceEdit:9027501] Varusai, Thawfeek, 2017-11-02 |
| schemaClass | Summation |
| text | Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1 F7) is a member of the IL-1 family. There are five isoforms of IL-37 (a-e) of which transcript IL-37b is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. IL-37 can bind the Interleukin-18 receptor 1 (IL-18R1) (Shi et al. 2003, Kumar et al. 2002). Upon binding to IL-18R1, IL-37 facilitates the recruitment of Single Ig IL 1 related receptor (SIGIRR, TIR-8, IL-1R8) forming a complex (Nold Petry et al. 2015). These events ultimately lead to suppression of cytokine production in several types of immune cells resulting in reduced inflammation. |
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