Reactome | Binding of RUNX2 to the CDKN1A gene promoter inhibits CDKN1A...

Schema > Summation > Entries

created	[InstanceEdit:9008467] Orlic-Milacic, Marija, 2017-06-09
dbId	9008468
displayName	Binding of RUNX2 to the CDKN1A gene promoter inhibits CDKN1A...
literatureReference	[LiteratureReference:9008431] Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype [LiteratureReference:9008386] Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter [LiteratureReference:9008464] Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice
modified	[InstanceEdit:9009782] Orlic-Milacic, Marija, 2017-06-22
schemaClass	Summation
text	Binding of RUNX2 to the CDKN1A gene promoter inhibits CDKN1A transcription, thus preventing CDKN1A-induced cell cycle arrest. Phosphorylation of RUNX2 by CDK4 in response to high glucose enhances RUNX2-mediated repression of the CDKN1A gene in endothelial cells (Pierce et al. 2012). HDAC6, which forms a complex with RUNX2, may contribute to RUNX2-mediated repression of CDKN1A in developing osteoblasts (Westendorf et al. 2002). In mice, Runx2-mediated repression of Cdkn1a may contribute to the development of acute myeloid leukemia (AML) (Kuo et al. 2009).

(summation)

Cite Us!