Reactome | Interleukin-35 (IL35) is a heteromeric complex conformed by ...

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created	[InstanceEdit:8983624] Varusai, Thawfeek, 2017-03-27
dbId	8983622
displayName	Interleukin-35 (IL35) is a heteromeric complex conformed by ...
literatureReference	[LiteratureReference:6809142] The composition and signaling of the IL-35 receptor are unconventional [LiteratureReference:8985396] Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase
modified	[InstanceEdit:8985450] Varusai, Thawfeek, 2017-04-16
schemaClass	Summation
text	Interleukin-35 (IL35) is a heteromeric complex conformed by Interleukin-12 subunit alpha (IL12A) and Interleukin-27 subunit alpha (IL27). IL35 can stimulate Janus Kinase (JAK)-bound homodimers of Interleukin-6 receptor beta precursor (IL6ST or gp130). JAKs are believed to be associated with the receptor before receptor activation (Behrmann et al., 2004). Subsequently, this triggers the phosphorylation of STAT1 downstream. The physiological consequence of this signalling is the suppression of T-cell response. The event is represented as a black box due to the incomplete knowledge about the ligand binding to monomers followed by dimerization or binding directly to the dimers.

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