Inferred from mouse: GRB2 associated binding protein 2 (GAB2...
| created | [InstanceEdit:8983295] Duenas, Corina, 2017-03-23 |
| dbId | 8983303 |
| displayName | Inferred from mouse: GRB2 associated binding protein 2 (GAB2... |
| literatureReference |
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| modified | [InstanceEdit:9024307] Duenas, Corina, 2017-10-03 |
| schemaClass | Summation |
| text | Inferred from mouse: GRB2 associated binding protein 2 (GAB2) is phosphorylated in response to Interleukin-2 (IL2) and Interleukin-15 (IL15) stimulation. Its phosphorylation is greatly diminished by mutation of the Y338 site in Interleukin-2 Receptor beta chain (IL2RB, IL2R?) that recruits SHC transforming protein 1 (SHC1) (Gadina et al. 2000, Wöhrle et al. 2009, Gesbert et al. 1998, Brockdorff et al. 2001). The core Interleukin-15 (IL15) receptor complex consists of IL15, Interleukin-15 receptor alpha subunit (IL15RA, IL15R?), Interleukin-2 receptor beta subunit (IL2RB, IL2R?), which is associated with JAK1 and Interleukin-2 receptor gamma subunit (IL2RG, IL2R?), which is associated with JAK3 (Johnston et al. 1995). In this event, the IL15 receptor complex also includes phosphorylated SHC1, GRB2 and GAB2. This is a black box event because the kinase responsible for GAB2 phosphorylation has not been demonstrated. |
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