Reactome | Tyrosine-protein kinase JAK1(JAK1) and Tyrosine-protein kina...

Schema > Summation > Entries

created	[InstanceEdit:8983267] Duenas, Corina, 2017-03-23
dbId	8983269
displayName	Tyrosine-protein kinase JAK1(JAK1) and Tyrosine-protein kina...
literatureReference	[LiteratureReference:539064] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15 [LiteratureReference:9009843] IL-15 Activates the Jak3/STAT3 Signaling Pathway to Mediate Glucose Uptake in Skeletal Muscle Cells
modified	[InstanceEdit:9014989] Duenas, Corina, 2017-08-07
schemaClass	Summation
text	Tyrosine-protein kinase JAK1(JAK1) and Tyrosine-protein kinase JAK3 (JAK3) are believed to be phosphorylated after stimulation of the Interleukin-15 receptor complex by Interleukin-15 (IL15) (Johnston et al. 1995), though it has been reported that only JAK3 phosphorylation increases in response to IL15 (Krolopp et al. 2016). The Interleukin-15 receptor complex consists of IL15, Interleukin-15 receptor alpha subunit (IL15RA, IL15R?), Interleukin-2 receptor beta subunit (IL2RB, IL2R?), which is associated with JAK1 and Interleukin receptor gamma subunit, which is associated with JAK3 (Johnston et al. 1995). This is a black box event since the mechanism by which IL15 promotes JAK phosphorylation is unclear.

(summation)

Cite Us!