Reactome | Signal transducer and activator of transcription 3 (STAT3) a...

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created	[InstanceEdit:8983249] Duenas, Corina, 2017-03-23
dbId	8983256
displayName	Signal transducer and activator of transcription 3 (STAT3) a...
literatureReference	[LiteratureReference:8983248] Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules [LiteratureReference:539064] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
modified	[InstanceEdit:9014989] Duenas, Corina, 2017-08-07
schemaClass	Summation
text	Signal transducer and activator of transcription 3 (STAT3) and Signal transducer and activator of transcription 5A/5B (STAT5A and STAT5B respectively or STAT5) dimers translocate from the cytosol to the nucleoplasm. 10 ng/mL Interleukin-15 (IL15) induces the nuclear localization of phosphorylated STAT3, unless inhibited by neutralizing anti-IL15 or anti-Interleukin receptor alpha subunit (IL15RA, IL15R?) mAbs (Giron Michel et al.2003, Johnston et al. 1995).This is a black box event because nuclear translocation of phosphorylated STAT3:STAT5 dimers has not been demonstrated but is inferred from other Jak-Stat signaling events.

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