Reactome | Signal transducer and activator of transcription 3 (STAT3) i...

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created	[InstanceEdit:8983249] Duenas, Corina, 2017-03-23
dbId	8983250
displayName	Signal transducer and activator of transcription 3 (STAT3) i...
literatureReference	[LiteratureReference:8983248] Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules [LiteratureReference:8983258] The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens [LiteratureReference:539064] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
modified	[InstanceEdit:9014989] Duenas, Corina, 2017-08-07
schemaClass	Summation
text	Signal transducer and activator of transcription 3 (STAT3) is believed to bind Signal transducer and activator of transcription 5A/5B (STAT5). IL15 stimulation leads to the formation of DNA binding complexes that contain STAT3 and STAT5 (Johnston et al. 1995, Giron-Michel et al. 2003). This is a black box event because dimer formation is inferred from STAT3 and STAT5 co-occurrence in DNA binding complexes.

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