Reactome | The DNA in the Pre-initiation complex is considerably compac...

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created	[InstanceEdit:8951718] Jupe, Steve, 2016-12-09
dbId	8951717
displayName	The DNA in the Pre-initiation complex is considerably compac...
literatureReference	[LiteratureReference:175852] HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro [LiteratureReference:170601] Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition [LiteratureReference:180108] LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes [LiteratureReference:180139] A previously unidentified host protein protects retroviral DNA from autointegration
modified	[InstanceEdit:8951719] Jupe, Steve, 2016-12-09
schemaClass	Summation
text	The DNA in the Pre-initiation complex is considerably compacted relative to its length when fully extended, probably due to binding of proteins in addition to the viral integrase. These proteins are not fully clarified, due to the difficulty of biochemical analysis of small amounts of material, but candidates include the viral NC and MA proteins, and the cellular HMGA, BAF, and PSIP1/LEDGF/p75 proteins. Purified integrase is capable of carrying out the terminal cleavage and initial strand transfer reactions.

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